// data ========================================================================================= // Make sure to follow the format. Careful with ' and " (") // Keep in chronological order // NEWS // format: Title, Date, Lab, image, abstract, detail // Lab MUST be one or more of: qcbr, lcms, alis, atoledo, jstarkus var strNewsFiltered = ""; var strNewsFilteredYears = ""; var arrNews = [ [ "Andrea's Birthday and Paper Publication Celebrations", "January 13, 2012", "lcms atoledo jstarkus", "/gallery/thumbnails/2012-01-13.jpg", "Celebrating Andrea's birthday and QCBR/LCMS' first paper acceptance this year.
View pictures of the celebration.", ""], [ "Dr. Andrea Fleig appointed board member of the Hawaii Academy of Sciences", "January 10, 2012", "qcbr lcms", "/QCBR/staff_images/AndreaFleig.jpg", "Dr. Andrea Fleig joins the board of the Hawaii Academy of Science, a private, non-profit organization promoting scientific research and education in Hawaii and the Pacific Rim. Founded in 1925, the Academy develops and executes programs and experiences for the science and learning communities, including the the Hawaii State Science & Engineering Fair, the Pacific Symposium for Science & Sustainability, and the Science Cafe. For more information please visit http://www.hawaii.edu/acadsci/academy.html", ""], [ "QCBR & ORD celebrates Christmas", "December 19, 2011", "lcms atoledo jstarkus", "/gallery/thumbnails/2011-12-19.jpg", "Congratulations to this year Christmas game winners:
Adriana, Dawn, Junhao, Haijie, Malika, Sue.
View pictures of the Christmas Party.", ""], [ "SFB894 meeting in Homburg, Germany", "December 5, 2011", "qcbr", "/QCBR/news/2011-12-05.jpg", "Reinhold was invited to present QCBR's most recent work at October's meeting of the GRAKO/SFB894 conference in Homburg, Germany.

From left to right: Drs. Jochen Deitmer, Andreas Beck, Reinhold Penner, Veit Flockerzi.
View a larger picture.", ""], [ "QCBR & ORD celebrates Thanksgiving", "November 21, 2011", "lcms atoledo jstarkus", "/gallery/thumbnails/2011-11-21.jpg", "Congratulations to this year Thanksgiving games winners:
Game 1: John (1st), Chad and Haijie (tied at 2nd).
Game 2: Andrea, Haijie, Jeff, Chris and Adriana.
View pictures of the Thanksgiving Party.", ""], [ "Collaboration between LCMS and Dr. David Horgen results in publication in JBC", "November 2, 2011", "qcbr lcms", "/QCBR/news/2011-11-02.jpg", "In collaboration with Dr. David Horgen, the LCMS has published the first known highly potent and specific TRPM7 inhibitor Waixenicin A, isolated from the Hawaiian soft coral Sarcothelia edmondsoni. The manuscript is published by the Journal of Biological Chemistry and features the cover page.", "
Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnesium-uptake mechanism in mammalian cells and are key regulators of cell growth and proliferation. They are abundantly expressed in a variety of human carcinoma cells controlling survival, growth and migration. These characteristics are the basis for recent interest in the channel as a target for cancer therapeutics. We screened a chemical library of marine organism-derived extracts and identified waixenicin A from the soft coral Sarcothelia edmondsoni as a strong inhibitor of overexpressed and native TRPM7. Waixenicin A activity was cytosolic and potentiated by intracellular free magnesium (Mg(2+)) concentration. Mutating a Mg(2+)-binding site on the TRPM7 kinase domain reduced the potency of the compound, whereas kinase deletion enhanced its efficacy independent of Mg(2+). Waixenicin A failed to inhibit the closely homologous TRPM6 channel and did not significantly affect TRPM2, TRPM4, and CRAC channels. Therefore, waixenicin A represents the first potent and relatively specific inhibitor of TRPM7 ion channels. Consistent with TRPM7 inhibition, the compound blocked cell proliferation in human Jurkat T-cells and rat basophilic leukemia cells. Based on the compound's ability to inhibit cell proliferation through Mg(2+)-dependent block of TRPM7, waixenicin A or structural analogs may have cancer-specific therapeutic potential, particularly since certain cancers accumulate cytosolic Mg(2+).

Waixenicin A inhibits cell proliferation through magnesium-dependent block of TRPM7. Zierler S, Yao G, Zhang Z, Kuo WC, Poerzgen P, Penner R, Horgen FD, Fleig A. J Biol Chem. 2011 Sep 16. [Epub ahead of print]. PMID: 21926172 [PubMed - as supplied by publisher]. Pubmed Link."], [ "QCBR & ORD celebrates Halloween", "October 31, 2011", "lcms atoledo jstarkus", "/gallery/thumbnails/2011-10-31.jpg", "Congratulations to this year's winners:
Costume contest: Junhao (1st), Chad (2nd), Kay (3rd).
Family Feud: Lori (1st), Mahea (2nd), Andrea (3rd).
View pictures of the Halloween Party.", ""], [ "Dr. Jun-Ichi Goto visits QCBR/LCMS during his honeymoon! Congratulations.", "October 21, 2011", "lcms", "/QCBR/news/2011-10-21.jpg", "Dr. Jun-Ichi Goto is a scientist from the RIKEN Institute in Saitama, Japan. He came to LCMS as a visiting scientist in 2009 and collaborated with Drs. Fleig and Penner. He is now married and on his honeymoon with his wife. While in Hawaii, he visited QCBR/LCMS. View a larger picture.", ""], [ "Emerson Kerwin earns the $1000 Scholarship award from the Coastal Mendocino Association of Realtors", "October 20, 2011", "lcms", "", "Emerson Kerwin won one of the 2010 scholarship awards from the Coastal Mendocino Association of Realtors (CMAR). Every year, CMAR rewards three students from their local community with a $1000 scholarship. Emerson is a talented student from the Mendocino High School. In 2009, he decided to enroll as a summer intern at the Laboratory of Cell and Molecular Signaling in Hawaii, under the supervision of Dr. Andrea Fleig. Read the full article at the CMAR website or view the PDF version.", ""], [ "Mahealani Promoted to Research Coordinator", "October 19, 2011", "qcbr lcms", "/gallery/thumbnails/2011-10-19.jpg", "Congratulations Mahealani. Mahealani will continue working on her Ph.D., while supporting the lab with administrative and financial tasks. View pictures of Mahea's promotion celebration.", ""], [ "Happy birthdays to Zheng Zhang", "October 05, 2011", "lcms", "/gallery/thumbnails/2011-10-05.jpg", "View pictures of Zheng's birthday celebration.", ""], [ "Farewell Lisa Janzon", "September 29, 2011", "lcms", "/gallery/thumbnails/2011-09-26.jpg", "View pictures of Lisa's farewell.", ""], [ "Farewell Drs. Annette Lis and Markus Thiel", "August 3, 2011", "lcms", "/gallery/thumbnails/2011-08-03.jpg", "Drs. Annette Lis and Markus Thiel both decided that it was best to return to Germany to raise their 10-months-old daughter. We will surely miss you guys! View pictures of their farewell party.", ""], [ "First RMATRIX & RTRN Speed Networking Café held at JABSOM", "June 30, 2011", "lcms", "/QCBR/news/2011-06-30.jpg", "On behalf of Dean Jerris Hedges and Dr. Richard Yanagihara, the RCMI Multidisciplinary and Translational Research Infrastructure Expansion (RMATRIX) and the RCMI Translational Research Network (RTRN) invited scientists to participate in a collaborative research event. This event gave an opportunity to interact with colleagues from diverse disciplines, find new collaborators, and discuss possible joint projects. A speed networking activity was followed by lunch and a chance to converse with fellow researchers at the University of Hawaii. View pictures of the event.", ""], [ "Happy birthdays to Christopher Maggio", "June 29, 2011", "lcms alis atoledo jstarkus", "/gallery/thumbnails/2011-06-29.jpg", "View pictures of Christopher's birthday celebration.", ""], [ "Euromag Meeting - Biology of Magnesium and its Transporters: Implications in Human Diseases. Bologna, Italy", "June 8-10, 2011", "qcbr lcms", "/QCBR/news/2011-06-08b.jpg", "
Image caption (view larger image): Maier, Fleig.

Dr. Andrea Fleig recently was invited to present the newest data on TRPM7 magnesium transport at the Euromag Meeting in Bologna, Italy. The Société internationale pour le Développement des Recherches sur le Magnésium, founded in
1901, will soon publicize its newly developed webpage at www.sdrmsociety.org. Here you will find up-to-date information on the latest news in the magnesium field.

Image caption (view larger image):
Standing: Lenardo, Ryazanov, Maier, Fleig Bindels, Gudermann, Barbagallo.
Sitting: Liu, Cho, Chubanov, Wolf, Weglicki, unknown, Touyz, Iotti.", ""], [ "Happy birthdays to Lori Tsue", "June 1, 2011", "lcms alis atoledo jstarkus", "/gallery/thumbnails/2011-06-01.jpg", "View pictures of Lori's birthday celebration.", ""], [ "Hawaii Cancer Consortium research team recognized by the Weinman Innovator Award for Translational Research, 2011", "May 25, 2011", "qcbr lcms", "/QCBR/news/2011-05-25.jpg", "The team of local experts representing three different disciplines with Dr. Andrea Fleig as Principal Investigator has been named recipient of the 2011 Weinman Innovator Award for Translational Research. The team will receive $50,000 in support of their work to develop a new potential therapeutic for clinical use in cancer. Dr. Fleig’s proposal is based on the discovery in her laboratory related to the critical role of the Mg2+-transporting ion channel TRPM7 in the regulation of cell growth and proliferation. Andrea and colleagues first discovered the molecular nature and the functional characteristics of TRPM7 (Nadler et al., Nature 2001). They further demonstrated its crucial role for cell growth and proliferation in vitro (Schmitz et al., Cell 2003) and more recently in vivo in transgenic animals (Ryazanova et al., Nature Comm. 2010).", "
While screening an in-house library of marine-derived natural products, they identified a highly selective inhibitor of TRPM7 with nanomolar potency, and exposure of tumor cell lines to this natural compound suppresses cell proliferation (Zierler et al., JBC, under review). Thus, they have identified a novel natural compound with anti-proliferative activity, whose mechanism is based on a highly potent and specific inhibition of Mg2+ transport via TRPM7. These mechanistic insights now pave the way for translational studies using suitable animal models of cancer, the first step in developing a potential therapeutic for clinical use in humans. The team brings together Drs. Andrea Fleig and Reinhold Penner from The Queen's Medical Center, Dr. David Horgen from The Hawaii Pacific University, and Dr. Toshihiko Kawamori from the UH Cancer Center. The annual Weinman award is funded as a component of the $1.7 million Weinman Foundation fund for Innovation endowment to the UH Cancer Center, provided by Virginia and Barry Weinman to support the development of cutting-edge cancer research.

Image caption: left to right - Horgen, Kawamori, Fleig, Penner, Weinman.
View larger version of the image above."], [ "Happy birthdays to Dr. Adriana Sumoza-Toledo", "April 28, 2011", "atoledo", "/gallery/thumbnails/2011-04-28.jpg", "View pictures of Dr. Adriana Sumoza-Toledo' birthday celebration.", ""], [ "Happy birthdays to Dr. Haijie Yu", "April 27, 2011", "lcms", "/gallery/thumbnails/2011-04-27.jpg", "View pictures of Dr. Haijie Yu birthday celebration.", ""], [ "The ORD/LCMS hosts the Nobel Laureate Seminar presented by Dr. Erwin Neher as guest speaker", "April 26, 2011", "qcbr lcms alis atoledo jstarkus", "/gallery/thumbnails/2011-04-26.jpg", "Dr. Erwin Neher received the 1991 Nobel Prize for Physiology or Medicine "for discoveries concerning the function of single ion channels in cells". Dr. Neher is a pioneer of cellular electrophysiology and developed a technique called the "patch-clamp" to measure the tiny currents flowing through single ion channels in cell membranes. View pictures of Dr. Neher's visit.", "
Dr. Neher presented his seminar "Signals and Signaling Mechanisms in the Central Nervous System" at the Queen's Medical Center (view seminar flyer in PDF). While at Queen's, he visited QCBR and shared his experience in the field. View larger version of the image above."], [ "Alex promoted to Coordinator, Department Information Systems I", "April 20, 2011", "qcbr lcms alis atoledo jstarkus", "/gallery/thumbnails/2011-04-20.jpg", "Alex provides information and computer support to the basic research at the Queen's Center for Biomedical Research (QCBR). His services now expands to the clinical research, as part of his integration with the Office of Research and Development (ORD). Congratulations Alex. View pictures of Alex' promotion celebration.", ""], [ "Dawn Tani promoted to Manager, Sponsored Programs", "April 11, 2011", "qcbr lcms alis atoledo jstarkus", "/gallery/thumbnails/2011-04-11.jpg", "Congratulations to Dawn Tani. Dawn has accepted the position of Manager, Sponsored Programs, in the Office of Research and Development (ORD). Dawn will start with ORD in mid-May. View pictures of Dawn's promotion celebration.", ""], [ "Dr. Andrea Fleig is appointed Director of Clinical Research", "March 21, 2011", "qcbr lcms", "/QCBR/news/2011-03-21a.jpg", "The Queen’s Medical Center (QMC) has announced the appointment of Andrea Fleig, Ph.D., as its Director of Office of Research and Development (ORD). Fleig is responsible for the compliant and successful execution of translational biomedical research at QMC through the development and administration of grants and contracts as well as the coordination of staff support for physicians conducting clinical trials at QMC’s Clinical Research Center.", "
Previously serving as the ORD Interim Director, Fleig was also the Associate Director of Research for 10 years at the QMC’s Center for Biomedical Research, where her work focused on how cellular signaling events relate to health and disease. Her research has earned R01- and P01-type Research Project Grants from the National Institutes of Health and more than 60 peer-reviewed publications and review articles.

In addition to her appointment, Fleig currently serves as an Adjunct Professor in the Department of Cell and Molecular Biology at the John A. Burns School of Medicine, University of Hawaii at Manoa and a Full Researcher with the University of Hawaii Cancer Center.

Fleig holds a doctorate in Biomedical Sciences with a focus on Neurosciences from the University of Hawaii at Manoa and a professorial degree in Zoology from the Georg-August University in Gottingen, Germany. Fleig was a postdoctoral fellow with the Department of Membrane Biophysics at the Max-Planck Institute for Biophysical Chemistry in Gottingen, Germany.

Current priorities of the Office of Research and Development include incorporating structured mentorship programs and start-up funding mechanisms focused on early-stage investigators in the areas of Neurosciences, Oncology, Nursing, Trauma, Cardiology and Biomedical Sciences.
View official press release (PDF). View pictures of Dr. Fleig's promotion celebration."], [ "Aloha to Christopher Maggio", "March 21, 2011", "qcbr lcms alis atoledo jstarkus", "/QCBR/news/2011-03-21b.jpg", "We are pleased to announce that Christopher Maggio joined our team as a research assistant. Christopher received a B.S. in Chemistry and Microbiology from the University of Florida in August 2010. As an undergraduate, he worked in the Virology Lab at the Entomology and Nematology Department of the University of Florida. He will be working in the laboratories of Drs. Andrea Fleig, Adriana Sumoza-Toledo, Annette Lis and John Starkus.", ""], [ "Happy birthdays to Dr. Junhao Huang and Mahealani Monteilh-Zoller", "March 9, 2011", "lcms", "/gallery/thumbnails/2011-03-09.jpg", "View pictures of Dr. Junhao and Mahealani birthdays celebration.", ""], [ "Congratulations to Dr. Zheng Zhang on his wedding", "March 4, 2011", "lcms", "/gallery/thumbnails/2011-03-04b.jpg", "Dr. Zheng is the fifth staff who got married while working at the Queen's Center for Biomedical Research, after dr. Annette Lis, dr. Markus Thiel, Clay Wakano and dr. Suhel Parvez. He returned to China for a month for his wedding. View Dr. Zheng's wedding pictures. He later returned to Hawaii, where we celebrated this happy moment with cake. View the QCBR celebration", ""], [ "Happy birthdays to Dawn Tani and Alexandre Guilloux", "February 07, 2011", "qcbr lcms alis atoledo jstarkus", "/gallery/thumbnails/2011-02-07.jpg", "View pictures of Dawn and Alex' birthdays celebration.", ""], [ "Dr. Reinhold Penner is appointed as Program Director of the Cancer Biology Program, UH Cancer Center, together with Dr. Joe Ramos as Co-Director", "February 01, 2011", "qcbr lcms", "/QCBR/news/2011-02-01.jpg", "", ""], [ "Farewell Stephanie Johne", "January 26, 2011", "lcms", "/gallery/thumbnails/2011-01-26.jpg", "Stephanie Johne was first hired as a Research Assistant in 2008 and later got promoted to Research Associate. She decided to pursue her career in Geneva, Switzerland. View pictures of Stephanie's farewell celebrations at QCBR, on a boat trip and at Doraku.", ""], [ "Dr. Lis' paper accepted in the Journal of General Physiology", "January 17, 2011", "alis", "/gallery/thumbnails/2011-01-17.jpg", "We are glad to announce that Dr. Lis paper titled "A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating" was accepted in the Journal of General Physiology. Read the abstract in PubMed. View the celebration pictures.", ""], [ "Appointment of Drs. Penner and Fleig as Full Researcher in the Cancer Biology Program at the University of Hawaii Cancer Center", "January 01, 2011", "qcbr lcms", "/QCBR/news/2002-07-14.jpg", "", ""], [ "Collaboration between UMDNJ, INRA and QCBR rewarded with publication in Nature Communications", "November 02, 2010", "qcbr lcms", "/QCBR/news/2010-11-02.jpg", "Nature Communications publishes collaborative work between UMDNJ, INRA and QCBR unraveling the central mechansims of mammalian magnesium homeostasis with implications for cancer cell proliferation. View more details at http://www.nature.com/ncomms/journal/v1/n8/full/ncomms1108.html.", ""], [ "The Journal of Physiology, May edition 588, features a Perspectives article on Dr. Starkus work investigating TRPM2 and proton permeation", "May 20, 2010", "jstarkus", "/QCBR/news/2010-05-20.jpg", "", ""], [ "Morten Larsen's first scientific paper has been accepted by Cell Calcium", "May 2010", "lcms", "/QCBR/news/2010-05-xx.jpg", "Morten can show that H2O2 activates CRAC currents through depletion of intracellular calcium stores. The story is the basis of his Masters thesis in Denmark. George and Morten collaborated on this effort and it is also George's first paper. Congratulations!", ""], [ "Dr. Andrea Fleig promoted to Adjunct Professor, Department of Cell and Molecular Biology, UH John A. Burns School of Medicine", "September 2010", "qcbr lcms", "/QCBR/news/2010-09-xx.jpg", "", ""], [ "Appointment of Drs. Lis and Sumoza-Toledo as Adjunct Assistant Professor, Department of Anatomy, Biochemistry and Physiology, UH John A. Burns School of Medicine", "May 1, 2010", "alis atoledo", "/QCBR/news/2010-05-01b.jpg", "", ""], [ "Welcome to our new Laboratories", "May 1, 2010", "qcbr alis atoledo jstarkus", "/QCBR/news/2010-05-01.jpg", "We are proud to announce that QCBR is now hosting three additional laboratories: the laboratory of Dr. Adriana Sumoza-Toledo, the laboratory of Dr. Annette Lis and the laboratory of Dr. John Starkus.", ""], [ "Dr. Adriana's Birthday Celebrations", "April 28, 2010", "lcms atoledo", "/gallery/thumbnails/2010-04-28.jpg", "Celebrating Adriana's birthday. View pictures of the celebration.", ""], [ "Emerson Kerwin wins place one at the Mendocino County Science Fair", "April 2010", "lcms", "/QCBR/news/2010-04-xxb.jpg", "Emerson Kerwin, former High School internship student with Dr. Fleig, wins place one at the Mendocino County Science Fair with work performed on mesothelioma cancer. With this he will present his poster at the California State Science Fair.", ""], [ "Dr. Andrea Fleig selected to present awards at this year's Hawaii State Science & Engineering Fair", "April 2010", "qcbr lcms", "/QCBR/news/2010-04-xx.jpg", "Dr. Fleig was honored to present awards at this year's Hawaii State Science & Engineering Fair on behalf of the The Queen's Medical Center. Previous students in her laboratory have won at this prestigeous event. For more information please visit the Hawaii Academy of Science Webpage.", ""], [ "Acceptance of George HK Myers at the University of Colorado School of Medicine to pursue his MD PhD degree", "March 30, 2010", "lcms", "/QCBR/news/2010-03-xx.jpg", "We have wonderful news: Congratulations to George H. Kenui Myers (!!) who has been accepted to the Medical Scientist Training Program at the University of Colorado School of Medicine to pursue an MD PhD degree.", ""], [ "Appointment of Dr. Andrea Fleig as Interim Director, Clinical Research, The Queen's Medical Center", "January 7, 2010", "qcbr lcms", "/QCBR/news/2010-01-07.jpg", "", ""], [ "Dr. Adriana's Birthday Celebrations", "April 28, 2009", "lcms atoledo", "/gallery/thumbnails/2009-04-28.jpg", "Celebrating Adriana's birthday. View pictures of the celebration.", ""], [ "Helen Altonn from The Honolulu Starbulletin reports about the findings resulting from the collaborative effort between Dr. Liu and QCBR", "February 23, 2009", "qcbr", "/QCBR/news/2009-02-23.jpg", "Isle doctors find new use for 1890s drug.
An old anti-leprosy drug might provide an effective treatment for three devastating autoimmune diseases—multiple sclerosis, psoriasis and type 1 diabetes—say two Hawaii researchers and mainland colleagues. Read the full article at the starbulletin or download the PDF version.", ""], [ "The collaborative effort between Dr. Jun O. Liu and LCMS highlighted in a press release", "January 30, 2009", "qcbr lcms", "/QCBR/news/2009-01-30.jpg", "The collaborative effort between Dr. Jun O. Liu from Johns Hopkins and our laboratory was recently highlighted in a press release: "Teaching an old drug new tricks" - Leprosy medicine holds promise as therapy for autoimmune diseases. Read the full press release at Johns Hopkings Medicine or download the PDF version.", ""], [ "The German Pfizer Research Prize for Medicine 2008 was awarded to Dr. Christine Peinelt", "December 01, 2008", "lcms", "/QCBR/news/2008-12-01.jpg", "Dr. Christine Peinelt was awarded the German Pfizer Research Prize for Medicine 2008 for "her ground-breaking work in the field of immune responses". The prize honors Dr. Peinelt's pivotal contribution to the elucidation of CRAC channels in 2006", ""], [ "Research study conducted at the University of Homburg/Saar in Germany leads to publication in Nature Cell Biology co-authoring Dr. Annette Lis.", "November 12, 2008", "alis", "/QCBR/news/2008-11-12", "JABSOM Research Fellow cited in Nature Cell Biology
NATURE CELL BIOLOGY reports this month on a discovery which could help in the treatment of diabetes, achieved by a team of researchers including DR. Annette Lis, now a post-doctoral fellow at the John A. Burns School of Medicine at The Queen's Medical Center.", "
The publication concerns a novel ion channel (called TRPM3) found in pancreatic cells which can be activated by pregnenolone sulphate.

The research was conducted at the University of Homburg/Saar in Germany, and co-authored by Lis, during her time there. Dr. Lis' contribution to the study was instrumental in identifying which of the 14 variants of the TRPM3 protein is functional in pancreatic beta cells. Those are cells which produce and release insulin, a hormone which controls the level of sugar (glucose) in the blood. The discovery that TRPM3 channels are present in those cells is significant, because they appear to be important for the release of insulin. Insulin release from beta cells is an important factor in diabetes, since some diabetics cannot release enough insulin to respond quickly to glucose changes in the blood. The researchers are hoping that activation of the TRPM3 channels, as they have demonstrated for pregnenolone, could be used to enhance insulin release in diabetes patients. The ultimate goal of further research would be to find pharmacological drugs that will stimulate the activity of TRPM3 and lead to novel approaches in the treatment of diabetes.

Dr. Lis continues to work on ion channels in The Queen's Center for Biomedical Research. She is currently conducting molecular research that may lead to the development of medicines targeting immune system disorders.

View article at JABSOM or download the PDF version."], [ "Clay Wakano , graduate student in Dr Turner's laboratory, successfully defended his Ph.D. Thesis in Molecular Biology, University of Hawaii at Manoa", "September 15, 2008", "lcms", "/QCBR/news/2008-09-15.jpg", "", ""], [ "Promotion of Dr. Annette Lis and Dr. Adriana Sumoza-Toledo to Research Scientist, Center for Biomedical Research, The Queen's Medical Center", "September 2008", "qcbr alis atoledo", "/QCBR/news/2010-05-01b.jpg", "", ""], [ "Shekinah Eugenio, NIDDK STEP-UP High School Program intern student places first amongst 11 graders for her presentation at the national scientific convention in Bethesda, MD", "August 29, 2008", "lcms", "/QCBR/news/2008-08-29.jpg", "", ""], [ "Dr. Suhel Parvez was awarded a Humboldt Foundation Fellowship to continue his research in Germany", "August 8, 2008", "lcms", "/QCBR/news/2008-08-08.jpg", "", ""], [ "Hawaii researchers make inflammation discovery", "August 6, 2008", "qcbr lcms", "/QCBR/news/2008-08-06.gif", "Researchers at The Queen's Medical Center and the University of Hawai'i John A Burns School of Medicine have made a discovery that could lead to an effective way to reduce inflammation in diseases including ulcerative colitis, according to a news release from the medical school.

The findings, published in the scientific journal NATURE (July 8, 2008), concern the cellular and molecular components which contribute to the development of inflammation.", "
The article is written by lead author Shinichiro Yamamoto of Kyoto University along with Drs. Ingo Lange, Andrea Fleig, and Reinhold Penner of the Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center and John A. Burns School of Medicine, according to the release.

The team's focus was on inflammation, which brings fluids, proteins and inflammatory cells to the affected tissue to enhance healing. However, too much inflammation can cause allergies and chronic diseases including rheumatoid arthritis or inflammation of the colon, the release said.

Researchers sought to discover whether an ion channel protein designated as TRPM2 was a factor in aggravating the inflammatory response. The researchers genetically altered a mouse to remove TRPM2. They experimentally infected the colon of the mouse to cause colitis, which triggers symptoms including diarrhea, bloody feces, body weight loss and ulcer formation. In the absence of the TRPM2, the severity of the colitis was strongly reduced. The research shows that therapeutic repression of TRPM2 ion channel activity may be an effective way to reduce the severity of inflammatory diseases, according to the news release.

The Queen's Medical Center's Laboratory of Cell and Molecular Signaling was established in July 1998 through a collaborative effort of The Queen's Medical Center and the University of Hawai'i. It is headed by Andrea Fleig, PhD and Reinhold Penner, MD, PhD.

View article at the Honolulu Advertiser or download the PDF version. "], [ "Ingo Lange, graduate student in the Drs. Fleig and Penner laboratory, successfully defended his Ph.D. Thesis in Biology, University of Erlangen, Germany", "July 14, 2008", "lcms", "/QCBR/news/2008-07-14.jpg", "", ""], [ "QCBR Collaboration with Dr. Yasuo Mori and Dr. Hiroshi Takeshima leads to publication in Nature Medicine", "June 9, 2008", "qcbr lcms", "", "View the article abstract or download the PDF version.", ""], [ "Marifel Barbasa, NIDDK-STEP-UP participant, won an "Outstanding Award" for the presention of her summer internship work given at the NIH STEP-UP symposium in Bethesda, Maryland", "September 5, 2007", "lcms", "/QCBR/news/2007-09-05.jpg", "", ""], [ "Dr. Alexander Stokes joins COBRE, JABSOM, University of Hawaii, Honolulu", "August 17, 2007", "qcbr", "/QCBR/news/2007-08-17.jpg", "", ""], [ "Appointment of Dr. Helen Turner as Dean of Natural Sciences and Mathematics at Chaminade University, Honolulu", "July 1, 2007", "qcbr", "/QCBR/news/2007-07-01.jpg", "", ""], [ "CRAC is more than CRACM1. CRACM2 and CRACM3 also form store-operated calcium channels, QCBR reports in Current Biology", "May 2007", "qcbr lcms", "", "", ""], [ "Senomyx licences QMC's TRPM5 patent rights covering modulation of sweet, bitter and savory tastes", "March 28, 2007", "qcbr lcms", "", "", ""], [ "CRACing the CRAC channel: Science Express - Molecular identification of the store-operated calcium influx pathway CRAC", "April 27, 2006", "qcbr lcms", "", "", ""], [ "Queen's Center for Biomedical Research discovery published in Molecular Cell - Reported by QMC Print Connection", "May , 2005", "qcbr lcms", "", "An astromomer may see a shiny, new object in the night sky and speculate about what it might be. Researchers at Queen's Center for Biomedical Research often see the equivalent of such an object, but at the molecular level. Recently, research at QCBR uncovered something interesting along the pathway to understanding ion channels and their role in major diseases. Read more details by viewing the PDF article.", ""], [ "Dr. Reinhold Penner nominated chairman of Nanopoint Inc.'s Scientific Advisory Board. Feature in Pacific Business News", "April 15, 2005", "qcbr lcms", "/QCBR/news/2005-04-15.jpg", "Reinhold Penner, 47, is the new chairman of Nanopoint Inc.'s Scientific Advisory Board. Nanopoint studies living cells using high-tech imaging systems. Read more details by viewing the PDF article.", ""], [ "Bret F. Bessac, graduate student in Dr. Fleig's laboratory, successfully defended his Ph.D. Thesis in Biomedical Sciences (Physiology), JABSOM, UHM", "March 10, 2005", "lcms", "/QCBR/news/2005-03-10.jpg", "", ""], [ "UH shares immune-system discovery. The finding holds big implications for AIDS, allergies, arthritis and organ transplants - Star Bulletin", "February 7, 2005", "qcbr lcms", "", "Hawaii researchers and mainland colleagues have discovered a mechanism in the body that can be used to boost the immune system to fight AIDS, cancer and other diseases.

Conversely, it can be used to reduce the immune response for organ transplants and debilitating autoimmune diseases, they report.

Read more details by viewing the full article at the Star Bulletin or download the PDF version. ", ""], [ "Cora Rillero, graduate student in Dr. Turner's laboratory, successfully defended her Masters Thesis in Cell Molecular and Biology, JABSOM, UHM", "December 9, 2004", "qcbr", "/QCBR/news/2004-12-09.jpg", "", ""], [ "Helena Morris, PRIDE program intern in Dr. Fleig's laboratory, was awared first prize for her platform presentation at the First Annual NIDDK Undergraduate Research Conference held at UMBC", "August 2004", "lcms", "/QCBR/news/2004-08-xx.jpg", "Helena Morris is a recent Kamehameha High School graduate and is currently involved in the Pacific Reg ion Diabetes Education program (PRiDE) at UH Manoa.", "
PRiDE is a new minority research program, which is affiliated with the Haumana and MARC programs. With the PRiDE program, students from high school through graduate levels join a professional laboratory and engage in current experiments. After thorough training those students will be assigned a specific project. Helena joined the LCMS team to gain real-world experience in laboratory procedures/experiments and a better understanding of the contemporary scientific world. She was awared "Honorable Mention - Platform Presentation" at the First Annual NIDDK Undergraduate Research Conference, UMBC, August 2004. Well done, Helena!"], [ "Mahealani K. Monteilh-Zoller, graduate student in Dr. Fleig's laboratory, successfully defended her Masters Thesis in Biomedical Sciences (Physiology), JABSOM, UHM", "August 2004", "lcms", "/QCBR/news/2004-08-xxb.jpg", "", ""], [ "Research at The Queen's Medical Center Yields Landmark Discoveries on Magnesium and Molecular Cell Biology - QMC Print Connection", "August 19, 2003", "qcbr lcms", "", "Magnesium is a mineral needed by every cell in your body. However, until recently, the minerals true importance, and the mechanism by which it enters into and comes out of cells, was unknown. Researchers at The Laboratory of Cell and Molecular Signaling, Center for Biomedical Re-search at The Queen's Medical Center and John A. Burns School of Medicine, University of Hawaii, are a part of an international collaboration which made recent discoveries on magnesium and its pathway, or ion channel, through the membrane of cells. The research was published in the journal Cell and featured as its cover article (Vol. 114, 191-200, July 25, 2003). Cell is the world's most prestigious biological science journal. Read the full details with the PDF.", ""], [ "Biomed research gets jolt - Pacific Business News", "August 10, 2003", "qcbr lcms", "", "A husband-and-wife team at Queen's Medical Center has learned something electric about the human cell, and it's sending a jolt of optimism around the world's biomedical community.

Reinhold Penner and Andrea Fleig of the Queen's Center for Biomedical Research have led research that has found the gatekeeping mechanism for an element critical to a healthy heart. Read the full details at the Pacific Business News website or the PDF version.", ""], [ "Hawaii biotech research featured", "August 5, 2003", "qcbr lcms", "", "The scientific journal Cell, read by biomolecular researchers around the world, features Hawaii research in its newest edition. The research concerns an element that the body needs to survive.

Queen's Medical Center and the John A. Burns School of Medicine at the University of Hawaii took part in an international project to identify the mechanism by which the body holds onto magnesium. "The Queen's Center for Biomedical Research provided the electrophysiological component of the research collaboration," Queen's said in a statement Monday. Read the full details at the Pacific Business News website or the PDF version.", ""], [ "Queen's Center for Biomedical Research findings are cover story in most prestigous journal of biomolecular study, CELL - QMC Print Connection", "August 4, 2003", "qcbr lcms", "/QCBR/news/2003-08-19.jpg", "First Discovery Of Ion Channel That is Essential for Cell Survival

HONOLULU—Researchers at The Laboratory of Cell and Molecular Signaling (LCMS), Center for Biomedical Research at The Queen’s Medical Center and John A. Burns School of Medicine are part of an international collaboration whose discovery is the cover story in the current issue of the scientific journal CELL. CELL represents the scientific community’s most prestigious journal of biology and biomolecular studies. Papers submitted for publication undergo stringent peer review.", "
The Queen’s Center for Biomedical Research provided the electrophysiological component of the research collaboration. The Queen’s Medical Center Medical Director Reinhold Penner, M.D., Ph.D. and Andrea Fleig, Ph.D. led the research which has discovered the ion channel in mammalian cells that maintains homeostasis of Magnesium, Mg. It is known that Magnesium is essential for life, but until this recent discovery it was unknown how to maintain this crucial mineral.

"In very basic terms, this is the first ion channel discovered in mammals that is essential for cell survival," commented, Andrea Fleig, Ph.D. "In our research we manipulated the cell to turn off the ion channel that maintains Magnesium levels and within 24 hours the cell died," she added. This ion channel exists in every cell of multi-cellular organisms. Ion channels are tiny pores that control the flow of substances in and out of every cell in the body.

The discovery of the homeostastis mechanism for Magnesium could be far-reaching for future studies leading to the detection and cures of common ailments. Magnesium plays a key role in heart disease, high blood pressure, migraines, osteoporosis, diabetes, asthma and numerous other diseases. This research also has major implications in managing cancer."], [ "Researchers at Queen’s solve major biochemical mystery - Star Bulletin", "August 3, 2003", "qcbr lcms", "/QCBR/news/2003-08-03.jpg", "Their findings on how cells use magnesium may help treat cancer

A discovery by two biomedical researchers at the Queen's Medical Center and others opens possibilities for new drugs and compounds targeting cancer cells and other diseases.

Drs. Andrea Fleig and Reinhold Penner and collaborators in Washington and Japan identified how magnesium, a crucial element for human health, gets into cells. Read the full details at the Pacific Business News website or the PDF version.", ""], [ "This week's issue of Cell (114, p191-200) features Carsten Schmitz, Anne-Laure Perraud and Andy Scharenberg's (Seattle) newest work in collaboration with the LCMS", "July 2003", "qcbr lcms", "", ""Regulation of Vertebrate Cellular Mg2+Homeostasis by TRPM7". The paper is featured on the journal's cover. Summary of the work as presented by Cell:
Despite the importance of magnesium ions (Mg2+) in many aspects of metazoan biology, little is known about how Mg2+ levels are regulated in and around vertebrate cells. Schmitz et al. show that the cation channel TRPM7 is an essential regulator of vertebrate cellular Mg2+ homeostasis and that intracellular Mg2+ itself inhibits the activity of the channel. This negative feedback mechanism has the potential to adjust Mg2+ uptake, thus maintaining proper intracellular Mg2+ levels. The authors present data suggesting that the atypical kinase domain of the channel is involved in this inhibitory feedback.", ""], [ "LCMS to present its latest work on TRPM ion channels at the Leopoldina Symposium on "Epithelial Transport of Ions in Health and Disease" in March 2003, Halle, Germany.", "December 2002", "qcbr lcms", "", "", ""], [ "Discoveries at Queen's May Lead to Breakthroughs in the Cure of Major Diseases - QMC Print Connection", "July 14, 2002", "qcbr lcms", "/QCBR/news/2002-07-14.jpg", "Discoveries at the molecular level of cells made at the Center for Biomedical Research at The Queen's Medical Center may lead to the successful management or cure to major diseases, including heart disease, stroke, allergies and diabetes. The work of Reinhold Penner, MD, PhD, Andrea Fleig, PhD, and other Queen's researchers was published in the journal Cell (Vol. 109, 397-407, May 3, 2002), the most prestigious biological science journal in the world.", "
"Humans and animals are highly complex organisms made up of organs, such as the heart, the brain or the liver," explains Penner, attempting to pinpoint the focus of his research. "Each organ is composed of smaller units called cells-like neurons of the brain that store our memories or muscle cells that contract the heart." Cells are isolated against each other, he continues, by plasma membranes, but they constantly "talk" to each other. Part of this communication is accomplished with charged ions (such as those of sodium, calcium and magnesium), which must pass into the cell across the plasma membrane via "ion channels." These ion channels are like little doors that open and close when cells communicate with each other. The QCBR paper in Cell describes the discovery of a previously unknown ion channel called TRPM4, which plays an important role in brain and heart cells. The malfunction of channels and the influx of various ions through these channels have been associated with disease.

The ultimate goal is to find drugs that will inhibit or stimulate the activity of ion channels to possibly stop, reverse or manage diseases. QCBR has been experimenting with many drugs and whole libraries of compounds. This area of research is one of the most promising in terms of curing or influencing the outcome of many major diseases."], [ "Leigh Anne Bagley, CMB graduate student in Dr. Fleig's laboratory, successfully defended her Masters Thesis", "June 2002", "lcms", "/QCBR/staff_images/LeighAnneBagley.jpg", "", ""], [ "Jason C. Barnhill is QCBR's first graduate student to successfully complete his masters degree in Dr. Helen Turner's Laboratory of Cell Biology and Immunology (LCBI).", "May 2002", "qcbr", "/QCBR/news/2002-05-xx.jpg", "Jason joined the Cell and Molecular Graduate Program in the Fall 2000 semester. His primary objective was to earn his masters degree and become a faculty member at the United States Military Academy.", "
A Captain in the U.S. Army, Jason Barnhill is the first of three full-time graduate students at the Queen's Center for Biomedical Research (QCBR) to successfully complete his program. Jason defended his MS thesis entitled "Structure-Function Relationships of Vanilloid Receptor Ion Channels", on March 22, 2002.

His work, under supervision of Dr. Turner, focused on a molecular biological analysis of ion channels that are key players in the pain pathway. Using an elegant fusion-PCR approach to generate chimeric ion channels, Jason was able to dissect critical functional regions in the 100kDa channel proteins.

A second aspect of his work, the analysis of a protein-protein interaction suggested by a two-hybrid screen, has resulted in the submission of a first author paper for Jason, entitled quot;Murine RGA gene product associates with TRPV2 channels during biosynthesis and trafficking". The abstract of this publication is available at www.fablab.org.

In addition, Jason developed several key mammalian cell culture systems that are in use to study the biology of the pain-transducing ion channels. Jason will now leave Hawaii for a posting as an instructor in Chemistry and Life Sciences at the prestigious US Military Academy, West Point. However, he hopes to come back to Hawaii for a PhD and get in a little more surfing, a pastime the Indiana native pickedup while here.

Jason has earned his masters degree and has become the first to graduate in the Cell and Molecular Biology Graduate Program offered through the John A. Burns School of Medicine at the University of Hawaii, where Dr. Turner is a faculty member."], [ "QCBR trains, benefits from top notch grad students - QMC Print Connection", "May 2002", "qcbr", "/QCBR/news/2002-05-xxa.jpg", "Having a scientific bent from an early age, Jason Barnhill always liked things that wriggled. A spring break in Florida turned him on to the marine sciences. Now he's at the Queen's Center for Biomedical Research (QCBR) studying the most miniscule of cell functions and will be off to teach at West Point in June. Read the full details with the PDF.", ""], [ "Molecule-sized discoveries make big news - QMC Print Connection", "June 25, 2001", "qcbr lcms", "", "Research on minuscule pores, or ion channels, in cells and electrical currents measured in millionths of a millionth of an amp could have big implications for the treatment of diseases like liver and kidney failure, blood disorders, stroke, immune system diseases and insulin shock. The research may even have implications on the damage to cells from aging. Get more details by reading the full PDF version.", ""], [ "Hawaii research finds the body electric - Star Bulletin", "June 5, 2001", "qcbr lcms", "/QCBR/news/2001-06-05.jpg", "Disease-fighting clout may increase with the discovery that all cells use chemical e-mail

Two Hawaii researchers and mainland colleagues have made discoveries about how animal cells work that may lead to treatments for stroke, heart attacks and many other disorders and diseases.

Findings of Drs. Andrea Fleig and Reinhold Penner of the Queen's Medical Center and University of Hawaii's John A. Burns School of Medicine and their associates were reported in two articles in last week's issue of the journal Nature. Read the full details at the Star Bulletin or the PDF version.", ""], [ "Research Findings at Queen's Make International News", "June 3, 2001", "qcbr lcms", "", "A Few Diseases That May Benefit: Blood Disorders, Liver and Kidney Failure, and Stroke
HONOLULU- For the second time in 2001, research performed in the laboratory of The Queen's Center for Biomedical Research (QCBR) at The Queen's Medical Center / UH John A. Burns School of Medicine is of such scientific significance that it has been published in Nature Magazine, the premier scientific research journal. Two QCBR/UH papers and findings are published back-to-back this week in Nature. Both studies look at the regulation of ion channels, tiny pores that control the flow of substances in and out of every cell in the body. The ion channels discovered here are LTRPC2 and LTRPC7. Get more details by reading the full press release (PDF).", ""], [ "Genetics seen as 'new industry' - Honolulu Advertiser", "January 1, 2001", "qcbr lcms", "/QCBR/news/2001-01-01.jpg", "With the genetic-research market booming, Hawai‘i medical research groups are positioning themselves and forming partnerships so the state can cash in on the growth.

"The sky’s the limit if we can facilitate health research in Hawai‘i," said Dr. David Curb, chief executive officer and medical director of the Pacific Health Research Institute, and a lead player in these moves. "It could be a new industry." Read the full details at the Honolulu Advertiser or the PDF version.", ""], [ "UH scientists find asthma, allergy key - Star Bulletin", "December 9, 2000", "qcbr lcms", "/QCBR/news/2000-12-09.gif", "They're working with two companies on drugs to take advantage of it.

Hawaii researchers have discovered the mechanism responsible for such common ailments as allergies and asthma and they're working with two pharmaceutical companies on drugs to control it.

Findings of the team, led by Dr. Reinhold Penner, are reported in this week's issue of the journal Nature.

The scientists represent the Center for Biomedical Research at The Queen's Medical Center and the University of Hawaii John A. Burns School of Medicine. Read the full details at the Star Bulletin or the PDF version.", ""], [ "TV Spot on KITV", "September 1999", "qcbr lcms", "", "", ""], [ "Partners in Research - Malamalama Journal", "December 1998", "qcbr lcms", "/QCBR/news/1998-12-xx.jpg", "New collaborators and old friends are boosting UH efforts in health research. Big money still comes from federal sources -- three UH units involved in biomedical research together bring more than $20 million. But don't discount local resources. Read the full details with the PDF.", ""], [ "Researchers eavesdrop on cells - Honolulu Advertiser", "July 1998", "qcbr lcms", "/QCBR/news/1998-07-xx", "For couple at UH, lure of Hawaii beats Harvard.

In a room on the second floor of the Biomedicl Sciences Building on the University of Hawaii's Manoa campus, human and mice cells jabber away while husband-and-wife researchers Reinhold Penner and Andrea Fleig listen in. Read the full details with the PDF.", ""], [ "The University of Hawai'i at Manoa's new Cell and Molecular Signaling Laboratory will be open to media for a special tour - UH News", "July 6, 1998", "qcbr lcms", "", "The new laboratory, established in conjunction with the Queen's Medical Center Neuroscience Institute, will be blessed and open to members of the University and medical communities at 4:30 p.m.", "
The laboratory is headed by the husband-wife team of Reinhold Penner and Andrea Fleig, who bring cutting-edge knowledge and techniques to the study of cellular function. The laboratory's main interest is focused on signal transduction, and the aim is to elucidate the functional properties of molecular components involved in the complex regulation of intracellular signaling in secretion, excitation-contraction coupling, cell proliferation, and apoptosis-processes that may play a role in stroke, tumor development and autoimmune diseases.

Previously with the famous Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, Penner is well known for his findings on calcium channels and how they affect communication or signaling among brain cells. He worked with Erwin Neher, the 1991 Nobel Prize winner in physiology and medicine.

Fleig, was a visiting researcher in UH's Békésy Laboratory of Neurobiology in 1989 and earned a PhD from UHM's Cell, Molecular and Neurosciences Program in 1993 before joining the Penner team. Read the original story at UH News or with the PDF version."] ]; // News Functions =============================================================================== function fnBuildNewsLatest(intLabID) { fnBuildNewsFilter(intLabID); // Run this before var arrNewsFiltered = strNewsFiltered.split(","); var strNewsHTML = "

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